A feasibility study in mini-pig for heart metabolism with hyperpolarized [1-13C]pyruvate: MRS cardiac modelling and kinetic considerations
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چکیده
F. Frijia, L. Menichetti, V. Positano, V. Lionetti, C. Forte, J. H. Ardenkjaer-Larsen, M. Milanesi, G. Giovannetti, D. De Marchi, G. Aquaro, M. Campan, F. A. Recchia, L. Landini, M. F. Santarelli, and M. Lombardi MRI Lab, "G. Monasterio" Foundation and Institute of Clinical Physiology, Pisa, Italy, Sector of Medicine, Scuola Superiore Sant'Anna, Pisa, Italy, Istituto per i Processi Chimico Fisici, CNR, Pisa, Italy, GE Healthcare, Huginsvej 8, 3400 Hillerod, Denmark, Department of Physiology, New York College, Valhalla, New York
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Background The heart normally derives most of its energy from the oxidation of fatty acids. Myocardial metabolism can be monitored non-invasively by MRS using hyperpolarized (HP) 13C-labelled compounds; however, the vast majority of studies reported have used HP pyruvate and did not measure fatty acid catabolism. The myocardial metabolism of HP [1-13C]butyrate and [1-13C]acetate has been report...
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تاریخ انتشار 2009